index - Laboratoire de recherche européen pour la polyarthrite rhumatoïde Access content directly

EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

Documents avec texte intégral

32

Références bibliographiques

134

Mots-clés

Genetic Predisposition to Disease Genotype Anti-Idiotypic European Continental Ancestry Group Disease maps Ankylosing spondylitis Rheumatoid Arthritis Patient ASSOCIATION STUDY Autoimmune thyroid diseases Association study Genetic Adult Receptors Network inference Systems biology Biologie des systèmes Adolescent APOPTOSIS Genetic Association Studies Single Nucleotide PTPN22 gene Young Adult Arthritis POLYMORPHISM Antigen Presentation Computational modeling Algerian population Europe Anti-citrullinated protein antibodies Computational systems biology Middle Aged In silico simulations Polyarthrite rhumatoïde Family Health Biocuration Phenotype Protein Tyrosine Phosphatase Female Databases Génétique African Continental Ancestry Group Human genomics France Computational biology Environment Aged Non-Receptor Type 22 Age Factors Analysis Rare variants Autoantibodies Shared Epitope Tunisia Rheumatoid arthritis Humans Biologie computationnelle des systèmes Antibodies Reproducibility Animals Genetics Linkage Disequilibrium Age of Onset Genetic Linkage Gene Frequency Logical modelling Alleles Autoantibody Production Rheumatoid Factor Antigens Rheumatoid Arthritis Family Ankylosing Complex genetic disease ABCB1 Binding Sites Male Cohort Studies Algeria HLA-DRB1 Polymorphism RHEUMATOID ARTHRITIS Annotation standards Hybrid modeling HLA-DRB1 Chains Odds Ratio Transcriptome Rheumatoid Epitopes Biological pathway Haplotypes 80 and over Metabolic reprogramming Autoimmunity Case-Control Studies Antirheumatic Agents HLA-DR Antigens Autoimmune Diseases Risk Factors ATP Binding Cassette Transporter Autoimmune thyroid disease

Derniers dépôts

Chargement de la page

Collaboration à l'international